One in four (25%) of patients suffering from depression, anxiety, or PTSD fail to improve with counseling and antidepressants. In this treatment resistant group, 3 out of 4 get rapid relief with IV ketamine infusion therapy, most after their first infusion. 

When ketamine work, it isn't subtle. Most responders remark that "they can't remember feeling this good before." These kind of responses make doing this work incredibly rewarding as we help people get their lives back.


Will ketamine work for you? Odds are it will... 75% of our clients, three out of every four! Won't you give IV ketamine therapy a try today? Give us a call now @ 352-325-5755.

Frequently asked questions

What is ketamine?

Ketamine is a medicine developed more than 50 years ago for anesthesia during surgery, and has been used for that purpose since that time in children, adults, and animals. More recently, ketamine has been found to be a valuable and highly effective treatment for depression, anxiety, and certain pain disorders.

How does it work?

Depression, anxiety, pain, and other forms of stress damage the communication system between areas of the brain responsible for memory, learning, and higher-order thinking. Ketamine is able to promote the materials necessary to make repairs to this damage within hours, relieving the depressive symptoms. It does so by triggering a cascading sequence of events in the brain, which ultimately results in the growth of new connections between neurons (brain cells) in the prefrontal cortex (front part of your brain).

What conditions does ketamine treat?

Major depression, the depressed phase of bipolar disorder (bipolar depression), postpartum depression, anxiety, post-traumatic stress disorder (PTSD), and obsessive compulsive disorder (OCD).

Is it safe?

The dose used for the treatment of mood and anxiety disorders is very low and safe. During ketamine treatments, blood pressure and heart rate may minimally increase but not sufficiently to cause issues. Using illegally-obtained ketamine on your own without a doctor’s supervision is a different matter. There is no assurance the substance you’re taking is actually ketamine at all, or that it hasn’t been mixed with other substances. And since ketamine is an anesthetic capable of sedating patients during major surgery, you can seriously injure yourself while under its influence if you are not in a controlled medical setting. If you are contemplating taking “street” ketamine in hopes of relieving your depression, keep in mind that the antidepressant effect depends on it being administered in a very precise, controlled way that you cannot achieve in a recreational setting.

Are there any conditions the would disqualify me from receiving ketamine?

Uncontrolled blood pressure, unstable heart disease, untreated thyroid disease, active substance abuse, current manic phase of bipolar disorder, or active psychotic (hallucinations or delusions) symptoms.

Are ketamine infusions covered by insurance?

Insurance companies are beginning to cover some of the costs of ketamine infusions. While we do not work directly with insurance companies, we provide you with everything you need to file a claim yourself! This includes a superbill (itemized statement) and a handy app, Reimbursify, to help you quickly file your claim. You can even file a claim online in just a few minutes! Each infusion is $349, which is $149 for the medical office visit and $200 for the infusion itself. Most insurance companies will pay at least a portion of the office visit. Some are now paying for the infusion itself. Out-of-network rates apply. Please check with your company to verify coverage. We do require payment at the time of service and accept cash, check, credit cards, HSA, FSA, and money orders.

Is financing available?

Yes, we have financing available for ketamine treatments through Advance Care Card. The financing application only takes 5 minutes and in most cases Advance Care is able to provide you with a credit decision immediately.

Do I need a referral from my doctor or therapist?

All patients are required to be evaluated by our staff and receive a history & physical. In some cases, patients may be asked for a written referral from their mental health or primary care provider. You should continue to see your mental health or primary health care provider for ongoing management of your mental health and before making any changes to your primary medication regimen.

Will it work for me?

About 75% of patients with treatment-resistant depression (including bipolar patients) experience rapid relief after a series of low-dose ketamine infusions. Similar success rates have been seen in those suffering from anxiety and/or PTSD. Treatment-resistant patients are those who fail to respond to traditional antidepressants and talk therapy. Before ketamine therapy, there was virtually no way to substantially improve the condition of these patients except for shock-therapy (ECT). The fact that ketamine works in as many as 3/4 treatment-resistant patients is astonishing. Its discovery has profoundly changed depression research and our understanding of the very nature of depression and other mood disorders. The only way to find out if it will work is to give ketamine a try. Are you ready?

What is it like to have a ketamine infusion?

Be sure not to eat food or drink fluids within 2 hours. Your initial consultation will last 15-30 minutes and includes discussion of the treatment and your medical history. You are welcome to bring a companion to be with you during your appointment, We recommend that you bring headphones and music that is relaxing for you. You will be placed in a comfortable recliner and an IV catheter will be gently inserted and the infusion started. The infusion itself lasts 40-60 minutes. Most find it a very pleasant, dreamy experience. About 5-10% shed tears during the infusion. A few become anxious during the infusion, which is easily managed with reasurrance, deep breathing, and slowing down the infusion rate. After the treatment you will be required to stay for a recovery period, typically 20-30 minutes. You will need to have an adult present to drive you home from your appointment.

Are there any side effects?

Short-term side effects are uncommon but may include mild increase in blood pressure and heart rate, dizziness, temporary blurred vision, sensation of "lightness" , euphoria, and nausea. Our patients are monitored continuously to ensure safety and medications to treat any sides effects such as nausea are readily available. There are no long-term side effects.

What should I bring to my first appointment?

You are highly encouraged to bring your medical records from your primary care provider or psychiatrist. If you have had recent lab work, please bring a copy of the results. Healthy patients do not require pre-infusion lab work. However, there are some medical conditions that may require assessment of labs prior to your first infusion and we will discuss this during your initial consultation. You may bring things like tablets, headphones, mp3 players and books. As a courtesy to other patients we ask that you please refrain from telephone conversations during your appointments. Complimentary ear plugs and eye covers are available for your use.

How quickly will I notice results?

It is possible to notice effects within 24 hours of a ketamine infusion. Many patients begin to benefit from symptom improvement within 2-4 hours, in some patients it may take up to 24-48 hours. You will fill out self-administered assessment questionnaires prior to each treatment to assess your response. For mental health conditions, most know within 2-3 infusions ketamine will help you. Some require all 6 initial infusions before they notice a difference. When it works, the changes are quite dramatic, not subtle at all. Ketamine responders feel less emotional pain, more hopeful, less sad, fewer thoughts of suicide, increased calmness, or become more inclined to engage with people. Additional improvements are often seen further into the course of treatment. If you are having positive results, it is recommended to have up to 6 total infusions within the first 2-3 weeks. After that, maintenance (booster) infusions may be scheduled to maintain response. The total length of treatment is highly dependent on each individual’s unique circumstances and results.

What medicines should I not take on the day of my infusion?

Generally, you should take all of your usual daily medications. If you take Lamictal (lamotrigine), Trileptal (Oxcarbazepine), benzodiazepines (Xanax, Valium, Ativan), gabapentin (Neurontin), or pregabalin (Lyrica), please skip the dose you would normally take immediately prior to your infusion. You can resume afterwards with your next scheduled dose. If you have medications that you only take as needed, such as benzodiazepines (Xanax, Valium, Ativan), opiates, or medical cannabis, it would be better that you NOT take these extra doses less than 6 hours prior to your infusion. You should also not drink alcohol the day of your ketamine infusion.

What about nasal esketamine?

Nasal esketamine (one half of the ketamine molecule) is more expensive and less effective than IV ketamine. It requires a two-hour observation in a clinic with each dose (you cannot take it home). Find out the truth about nasal esketamine here.

Do you have private infusion rooms?

All of our infusion rooms are private. We provide a warm, healing environment with reclining massage chairs and dimable lights.

Do you have an article I can read for more info?

Absolutely! Here is a recent article that Dr. Milbrandt wrote for Health & Wellness Magazine.

What is ketamine-assisted therapy?

Ketamine-assisted therapy is a one-on-one ketamine session with a Certified Trauma Professional. Whether it's trauma from childhood or something more recent, Dr. Milbrandt will help you to let go of the pain that is holding you back from recovery.