Supportive Oligonucleotide Technique (SOT)

Now only $2149 per SOT!!!

SOT is a treatment for Lyme bacteria, co-infections, and other viruses like EBV, HSV, CMV, Varicella and others. This breakthrough therapy utilizes short DNA or RNA segments to block the expression of critical segments of genes needed for Lyme or viruses to survive and replicate.


Essentially SOT creates a shutoff “key” that precisely fits a chosen “lock” portion of a pathogen. The “lock” is a specific section of DNA that normally controls an important function of the pathogen. The “key” binds to the “lock” and blocks the function thus eliminating the pathogen. Afterwards, the SOT compound is released and travels to the next target, thus fighting the infection 24/7 for 3 to 6 months.

Check out the SOT FAQ

The figure shows an example of a pathogen such as the Lyme bacteria. Inside the cell nucleus (yellow), bacterial DNA is used to transcribe messenger RNA (mRNA). The mRNA is sent out of the nucleus into the main part of the cell, the cytoplasm. It is there that mRNA is used to join amino acids together into proteins that are essential for a variety of bacterial activities, including reproduction. SOT works by creating a short segment of complementary DNA in the lab that binds to the specific mRNA segments and prevents the bacteria from making essential proteins, essentially shutting off bacterial replication. Unable to replicate, the bacteria is unable to cause disease.

This video explains SOT in visual detail. Though it describes SOT for cancer therapy rather than treatment of infections, the techniques are essentially the same. This Facebook group, S.O.T. for Lyme, EBV & Co-infections (supportive oligonucleotide therapy), is a great resource for additional information. Another good source is The Genesis Center's Lyme Page.

Years of clinical experience from around the world are showing that long term suppression of treated viruses or Lyme is likely (but not guaranteed) and that symptoms associated with these diseases are usually greatly diminished or eliminated.

SOT is not a drug in the traditional sense. It is not an antibiotic nor is it gene therapy. It does not change the genetic structure. There are no gene splicing, gene insertion, or manipulation. SOT therapy is a stealth technology with molecules so small that they are able to avoid detection and destruction by the immune system or RNA degrading enzymes for months, allowing them to quietly circulate through the body, attaching to their viral or bacterial targets.

SOT Protocol

To make a diagnosis of infection and/or to most accurately gauge response between SOT treatments, we recommend using the PrimeSPOT test though RGCCs affiliate lab, Biocentaur. However, any confirmation of infection through a recognized US lab within 6 months prior to ordering a SOT is sufficient to start therapy. 

The patient’s blood is drawn to obtain circulating Lyme bacteria or viruses. The blood is sent to RGCC laboratory Greece. RGCC lab identifies the main genetic sequence of the target replication genes for the organism, then creates a complementary oligonucleotide (short nucleic acid) sequence to block replication. RGCC ships the SOT to the patient's clinic, where it is infused intravenously over about an hour. Intravenous antihistamines and low dose steroids are given immediately prior to SOT administration in order to lessen the already rare chance of an allergic reaction and tighten the vein walls to minimize leaking of SOT. The main side effects of SOT treatment are detox or "Herx" reactions, such as fatigue, body aches, and headache. Patients who have gone through treatment will often say “your symptoms get worse before they get better.” The SOT may be repeated up to 3x per year if needed. With each round of SOT it is recommended to retest for the presence of pathogens. At some point the infection may be completely eradicated or remain stable in a quiet remission. 

SOT Cost

One SOT costs ~$2149. This is ~$1550 to have the SOT made by RGCC + $299 for the office visit & consult + $300 for IV infusion of the SOT. Additional SOTs ordered from the same blood draw are only $1850 each ($1550 for the SOT, $300 for the IV infusion).

Labwork costs. The initial PrimeSPOT test is $1,350, though you can avoid this cost by providing a confirmation of infection from a recognized US lab with the last 6 months. Follow-up PrimeSPOTs within 6-months are only $200.