Supportive Oligonucleotide Therapy (SOT)

First SOT $2149, Additional SOTs $1850 each*

SOT is a treatment for Lyme bacteria, co-infections, and other viruses like EBV, HSV, CMV, Varicella and others. This breakthrough therapy utilizes short DNA or RNA segments to block the expression of critical segments of genes needed for Lyme or viruses to survive and replicate.


Essentially SOT creates a shutoff “key” that precisely fits a chosen “lock” portion of a pathogen. The “lock” is a specific section of DNA that normally controls an important function of the pathogen. The “key” binds to the “lock” and blocks the function thus eliminating the pathogen. Afterwards, the SOT compound is released and travels to the next target, thus fighting the infection 24/7 for 3 to 6 months. 

The figure shows an example of a pathogen such as the Lyme bacteria. Inside the cell nucleus (yellow), bacterial DNA is used to transcribe messenger RNA (mRNA). The mRNA is sent out of the nucleus into the main part of the cell, the cytoplasm. It is there that mRNA is used to join amino acids together into proteins that are essential for a variety of bacterial activities, including reproduction. SOT works by creating a short segment of complementary DNA in the lab that binds to the specific mRNA segments and prevents the bacteria from making essential proteins, essentially shutting off bacterial replication. Unable to replicate, the bacteria is unable to cause disease.

Questions about Testing

What labs do I need for an SOT?

Any positive test for Lyme or co-infections done within 6 months of ordering the SOT is valid. This is ESSENTIAL and RGCC makes no exceptions. The reasoning is that the SOT they make for you is for your specific strain of Lyme (or other organisms). It is NOT some generic anti-Lyme therapy but designed specifically for you. Without being able to find Lyme (or other infections) in your blood, RGCC would be unable to make the correct SOT for you.

What are PrimeSPOT and PaldiSPOT? How much to they cost?

These are tests we offer through BioCentaur, a sister company of RGCC. PrimeSPOT - Screens for viruses (HSV, EBV, CMV, HPV, HTLV, HBV, HCV, HIV) and the presence of Lyme Disease-associated species (Borrelia and Babesia NOT Bartonella). When Lyme is detected, it does not give you the exact species but an SOT can be made to match it regardless. Cost ~$1350 PaldiSPOT - Screens for the presence of 23 of the most common strains of Borrelia, Babesia and Bartonella genospecies. Cost ~$1100 (20% discount if ordered with PrimeSPOT).

Which organisms does PaldiSPOT test for?

 Borrelia burgdorferi
 Borrelia afzelii
 Borrelia garinii
 Borrelia mayonii
 Borrelia lusitaniae
 Borrelia valaisiana
 Borrelia kurtenbachii
 Borrelia lanei
 Borrelia californiensis
 Borrelia bissettiae
 Borrelia bavariensis
 Borrelia turcica
 Borrelia spielmanii
 Borrelia carolinensis
 Borrelia americana
 Borrelia sinica
 Borrelia yangtzensis
 Borrelia hermsii
 Bartonella henselae
 Bartonella bacciliformis
 Bartonella vinsonii
 Babesia microti
 Babesia duncnani

Are my test results enough to order an SOT?

If you are unsure, just email us your test results to us with a description of what SOTs you are looking to order. We will review your results and let you know if they are sufficient.

Which organisms can you order an SOT for?

Borrelia: B. burgdorferi, B. mayonii, B. garinii, B. bissettii, B. bavariensis, B. valaisiana, B. afzelii, B. finlandensis, B. recurrentis, B. genomospecies, B. hermsii, B. lusitaniae, B. sinica, Candidatus B. tachyglossi, B. miyamotoi Bartonella: B. henselae, B. bacilliformis, B. vinsonii, B. quintana, B. elizabethae Babesia: B. microti, B. bigemina, B. divergens, B. duncani, B. bovis Viruses: HHV1/HSV1 (Human Simplex Virus-Oral-Facial), HHV2/HSV2 (Human Simplex Virus-Genital), HHV6 A & B (Human Herpes Virus 6), CMV (Cytomegalovirus), Coxsackie Type A & B, VZV (Varicella-Zoster (shingles)), EBV (Epstein Barr), HPV 6/11/16/18 (Human papillomavirus), HBV (Hepatitis B), HCV (Hepatitis C), HIV (Human Immunodeficiency Virus),  HTLV1— (Human T-cell Lymphotropic Virus)

What if I have more questions?

Check out our extensive SOT FAQ or call us at 352-325-5755

How long does it take to get an SOT?

Typically 4 to 6 weeks after the blood is drawn.

Can I get more than one SOT at a time?

You can order several SOTs from one blood draw but can only be infused with one SOT at at time. We generally recommend at least one to two weeks between infusions to avoid overlapping Herx reactions.

Can I have the blood drawn by someone else?

The blood for PrimeSPOT, PaldiSPOT, and SOTs must be drawn at our clinic and cannot be done at an outside lab. We cannot ship a specimen kit to you. RGCC strictly enforces this.

How successful is this for Lyme?

The top 2 practitioners in the US report a 96% success rate for Lyme. RGCC says this as well, but has not published the data. For other organisms, SOTs are too new to know for sure. Response to SOT depends on a variety of factors, including number of organisms involved and how long the infection(s) have been present. Your best source of unbiased, real-world experience and outcomes with SOT is the Facebook SOT Group.

How many SOTs are required to treat Lyme? EBV? Other infections?

Most Lyme and co-infections (Borrelia, Babesia and Bartonella) are effectively treated with a single SOT for each organism. Viruses, such as EBV, often take two or three SOTs spaced 4-6 months apart.

How much does an SOT cost?

Your first SOT costs ~$2149. This is ~$1550 to have the SOT made by RGCC + $299 for the office visit & consult + $300 for IV infusion of the SOT. Additional SOTs ordered from the same blood draw are only $1850 each ($1550 for the SOT, $300 for the IV infusion).

How long after SOT before I feel better?

This varies from person to person. Most people start to notice improvements around the 6-month mark. Some notice sooner.

What is herxing?

A Jarisch–Herxheimer "Herx" reaction is a reaction to endotoxin-like products released by the death of harmful microorganisms within the body during antibiotic treatment. Efficacious antimicrobial therapy results in lysis (destruction) of bacterial cell membranes, and in the consequent release into the bloodstream of bacterial toxins, resulting in a systemic inflammatory response. It usually manifests in 1–3 hours after the first dose of antibiotics as fever, chills, rigor, hypotension, headache, tachycardia, hyperventilation, vasodilation with flushing, myalgia (muscle pain), exacerbation of skin lesions and anxiety. The intensity of the reaction indicates the severity of inflammation. Reaction commonly occurs within two hours of drug administration but is usually self-limiting.

Do I have to stop my other Lyme treatments?

Before blood draws for testing or SOTs, you should stop all Lyme treatments, especially antibiotics. For your SOT infusion, you only need to stop treatments the day of your infusion and can resume the following day. They will not interfere with the SOT.

Additional Information

This video explains SOT in visual detail. Though it describes SOT for cancer therapy rather than treatment of infections, the techniques are essentially the same. This Facebook group, S.O.T. for Lyme, EBV & Co-infections (supportive oligonucleotide therapy), is a great resource for additional information. Another good source is The Genesis Center's Lyme Page.

Years of clinical experience from around the world are showing that long term suppression of treated viruses or Lyme is likely (but not guaranteed) and that symptoms associated with these diseases are usually greatly diminished or eliminated.

SOT is not a drug in the traditional sense. It is not an antibiotic nor is it gene therapy. It does not change the genetic structure. There are no gene splicing, gene insertion, or manipulation. SOT therapy is a stealth technology with molecules so small that they are able to avoid detection and destruction by the immune system or RNA degrading enzymes for months, allowing them to quietly circulate through the body, attaching to their viral or bacterial targets.

SOT Protocol

To make a diagnosis of infection and/or to most accurately gauge response between SOT treatments, we recommend using either PrimeSPOT or PaldiSPOT through RGCCs affiliate lab, Biocentaur. However, any confirmation of infection through a recognized US lab within 6 months prior to ordering a SOT is sufficient to start therapy. 

The patient’s blood is drawn to obtain circulating Lyme bacteria or viruses. The blood is sent to RGCC laboratory Greece. RGCC lab identifies the main genetic sequence of the target replication genes for the organism, then creates a complementary oligonucleotide (short nucleic acid) sequence to block replication. Four to six weeks after the initial blood draw, RGCC ships the SOT to the patient's clinic, where it is infused intravenously over about an hour. Intravenous antihistamines and low dose steroids are given immediately prior to SOT administration in order to lessen the already rare chance of an allergic reaction and tighten the vein walls to minimize leaking of SOT. The main side effects of SOT treatment are detox or "Herx" reactions, such as fatigue, body aches, and headache. Patients who have gone through treatment will often say “your symptoms get worse before they get better.” The SOT may be repeated up to 3x per year if needed. With each round of SOT it is recommended to retest for the presence of pathogens. At some point the infection may be completely eradicated or remain stable in a quiet remission. 

SOT Cost

*One SOT costs ~$2149. This is ~$1550 to have the SOT made by RGCC + $299 for the office visit & consult + $300 for IV infusion of the SOT. Additional SOTs ordered from the same blood draw are only $1850 each ($1550 for the SOT, $300 for the IV infusion).

Labwork costs. The initial PrimeSPOT test is ~$1,350. PaldiSPOT is ~$1100, though you can avoid this cost by providing a confirmation of infection from a recognized US lab with the last 6 months. Follow-up PrimeSPOTs within 6-months are only $200. There is no 6 month follow-up discount with PaldiSPOT.